The EXPEED 5 image-processing engine built into the D5 delivers low noise, the high-speed processing required for 4K UHD video, and high-speed continuous shooting at approximately 12 fps (with AF and AE tracking). Up to 200 14-bit lossless-compression RAW images can be captured with a single burst of continuous shooting. The new Multi-CAM 20K autofocus sensor module is very densely packed with 153 focus points (99 are cross-type sensors positioned in central and peripheral areas) covering a broad area of the frame. What's more, still JPEG images with a pixel count of roughly 8 megapixels can be extracted from 4K UHD movies, the D5 supports the highest standard sensitivity in Nikon history — ISO 102400, and with an AF detection range beginning at just −4 EV, autofocusing on dimly lit and low-contrast subjects is possible.

Adoption of the new EXPEED 5 image-processing engine and a new Nikon DX-format CMOS sensor for the D500 has achieved a broad standard sensitivity range — ISO 100–51200, expandable to the equivalent of ISO 1640000 (Hi 5). The D500 delivers high-speed continuous shooting at up to approximately 10 fps (with AF and AE tracking) for up to 79 shots of 14-bit uncompressed RAW images in a single burst. Along with stills, the D500 supports recording of 4K UHD (3840 x 2160)/30p, full-HD, and time-lapse movies. It is equipped with a 3.2-inch, approximately 2,360K-dot touch screen monitor for viewing and shooting ease. The camera can record to both XQD and SD card slots at the same time, and is compatible with SnapBridge for seamless connection of the camera to a smart device, allowing users to transfer and share images.

SnapBridge enables seamless connection of a camera and smart device with an energy-efficient Bluetooth low energy connection. Once installed, SnapBridge enables immediate transfer of images to a smart device from the camera with which up to five smart devices can be paired. Original JPEG images, or smaller 2-MP (full HD) JPEG copies can be automatically transferred to, and stored on, smart devices during shooting. In addition, two types of embedded information, including copyright, shooting information, comments, and logos, can be included. Further, the app supports remote shooting from the smart device, allowing users to frame and preview shots in real time using the smart device screen and, with certain cameras, to operate features such as the self-timer.